Guardiola's comprehensive domination of United boss Jose Mourinho can only be viewed as embarrassing for the Old Trafford club that has viewed the local foes with jovial pity down the years, with the style divide that separates these two sides arguably more damaging to the United manager than the huge points gap City establish before Christmas.
"I think Manchester City is too good for Liverpool over two legs". "If we do that well they will have some difficulty coping with it", he said. "Winning a title over our biggest rivals can put us in City's history, and make the fans very happy".
Guardiola suggested after that game that his players may not have dealt with the atmosphere well as the Reds scored three goals in a blistering 10-minute spell in the second period.
"We lost a bit of control [in the last meeting]; we were involved in the environment of Anfield".
"Not just [Salah], Mane and Firmino, all three, they are nearly unstoppable".
If we are able [we make the] semi-finals, if we are not able [we say] well done Liverpool and next season we come back stronger to overcome the situation we can not this season. 'We won a lot of things together and we lived through many experiences. They are fantastic, fantastic players and the way Liverpool plays is so complicated for us.
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"I'm aware that the overall feeling is positive towards me but I have no idea what exactly the fans think of me". Do we know we have a chance?
However, with Sergio Aguero, Gabriel Jesus, Leroy Sane and Raheem Sterling at his disposal, the tie looks to have the potential to be absolutely laden with goals.
'I would say that of all the match-ups, and each one is great in its own right, if I were a neutral spectator I would choose this game.
De Bruyne said: "The first half, especially, was the best football we have played this season".
"They didn't know what to do".
"We see our chance but we know it will be unbelievably hard. I said, 'See you soon" and sent him a little smiley emoji, to which he answered with a smiley as well'.