Son was handed a start by Pochettino at Wembley on Saturday against Huddersfield Town and netted both his side's goals in a 2-0 win over David Wagner's men.
Llorente suddenly exploded into life during Wednesday's 6-1 FA Cup victory over Rochdale, scoring three goals in the space of 12 minutes.
Son had already appealed for a penalty, after being brought down by a clumsy challenge from Terence Kongolo, when Spurs responded to Ince's effort by nearly immediately scoring their second goal and securing all three points.
Spurs last progressed to the quarter-finals of the Champions League in 2011, when they also faced Italian opposition in the last 16.
And that trio should have put Spurs out of sight of a limited Huddersfield in the first 45 minutes.
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The South Korean has been directly involved in 13 goals in his last 11 Premier League appearances at the national stadium and Tottenham fans will be hoping he can continue to produce that form for the remainder of the season.
The north London club will go through on the away goals rule if they can keep a clean sheet in the return leg, but Pochettino said he will set up his team to play on the front foot like in the first leg.
In the 54th minute from space on the right wing, Kane whipped a masterful cross into the area that Son ran onto at the back post and met with a well-timed header Lossl had little chance to save.
Kane may have failed to score for a sixth straight game, but the England striker deserved most of the credit for Son's second, though, as his wonderful cross picked out his teammate perfectly.
"He's not a machine and he needs to rest", added Pochettino when quizzed on why Son had been withdrawn when on a hat-trick.
Kane had a late header disallowed for offside after the impressive Christian Eriksen found him with a corner.