The Home And Away actress has been fighting for her life since a Boxing Day auto crash on the NSW South Coast killed her parents Lars, 69, and Vivian, 60, and younger sister Annabelle, 21.
Doctors have performed multiple surgeries on the 29-year-old Falkholt - including reportedly removing a portion of her skull and one of her kidneys - in an effort to save her life.
The hospital on Friday confirmed Jessica's life support had been switched off, saying it will provide the next update on Jessica's condition at midday and again at 4.30pm.
Jessica Falkholt's family were killed in a auto crash on Boxing Day.
On Thursday night, Jessica had her life support switched off weeks after the horrific accident on the New South Wales south coast, making her the fifth victim of the Boxing Day crash that killed her parents and sister. My deepest condolences to Jessica Falkholt's loved ones.
Jessica's family were farewelled at a ceremony at St Mary's Catholic Church in Concord on Wednesday.
Jessica's parents died at the scene and her sister's life support was turned off three days after the two-car collision.
Falkholt's parents, Lars, 69 and Vivian, 60, were killed instantly in the Boxing Day crash.
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He added that both children and pregnant women are among those at higher risk due to the flu, as are people over the age of 63. However, some have chronic health problems and the flu can lead to complications ranging from moderate to life-threatening.
Jessica, 29, and her sister Annabelle, 21, were pulled from the burning vehicle by witnesses.
Vivian's younger brother, Paul Ponticello, spoke at the funeral service where he thanked people who ran to the family's aid.
Police believe the crash occurred when a large vehicle crossed the centre line and crashed head on with the Falkholt family's auto.
"Whenever he'd ask to drive somewhere - I'd suggest a time for an average driver and add on some additional time for the "Lars factor" because he was so careful". We always had a good laugh.
Our thoughts are with the Falkholt's family and friends at this hard time.
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Harmony was the last movie Jessica filmed before the horror crash last month.