His son, Eric Trump tweeted out thanks for first responders.
"We made several announcements to all the tenants in the building to remain in place", said New York Fire Chief Roger Sakowich.
Trump was in Washington, where he has lived since he was elected president. "The men and women of the #FDNY are true heroes and deserve our most honest thanks and praise!" he posted on micro-blogging site Twitter.
Can California preserve net neutrality? Lawmakers pledge to try
Before this, a lot of the same big tech companies were fairly passive and inactive during the initial protests of the repeal. This repeal of the net neutrality rules will hurt us and many small businesses in Montana, let alone across the country.
Trump Tower was also the setting for Trump's reality TV show, "The Apprentice", and the headquarters of his presidential campaign.
The president, who has a penthouse residence in the tower, as well as business offices there, is not believed to be at the midtown, Manhattan tower block at this time.
The president was at the White House when fire engines with flashing emergency lights clogged the streets around his Fifth Avenue luxury building during the morning rush-hour.
There was no immediate report of injuries, or what caused the smoke-filled scene.