Set up by a 27-yard precision pass from Brady to Danny Amendola on the sideline the Patriots would put the first points of the day on the board. The 44-yard run was the longest of Lewis' career.
Tom Brady went 21 of 30 for 258 yards and an interception, while improving to 27-3 over Buffalo and breaking Brett Favre's National Football League record for most wins by a quarterback against any one opponent.
The Bills would receive their offense in the first half from an unlikely source in that of a special teamer and backup quarterback Joe Webb.
A third field goal of the half for the Patriots would make the score 9-3 going into halftime.
Thursday Weather: Another Cooler Day
However, a big change in our weather pattern is looking likely late next week with much cooler weather heading our way. Temperatures take a slight dip Friday into the mid 60s, and overnight lows drop to the upper 30s and lower 40s.
Sunday will mark Brady's fifth December game in western NY, with the first coming in 2001 and proving to be one of the most memorable. Peterman finished 6 of 15 for 50 yards in three series.
The Patriots will receive the ball to begin the second half. The defense would feed off the momentum of their offense as the quickly forced a Bills punt following a big David Harris sack on third down on the very next possession. The highlight: A 30-yard reception down the right sideline that he ripped away from Buffalo rookie corner Tre'Davious White.
Tom Brady completed 21 of 30 passes for 258 yards, while Rob Gronkowski starred in the second half as the Patriots won their 14th successive road game.
After taking on sack on the first snap of the game, Taylor marched the Bills 66 yards and down to the five yard line, before throwing an interception to Patriots linebacker Eric Lee.
Bills quarterback Tyrod Taylor was carted to the locker room with a knee injury early in the fourth quarter and did not return.