Kizer, though, made what appeared to be a major mistake at the end of the first half.
The Lions forced a fumble after a completed pass and fourth-year cornerback Nevin Lawson returned the turnover 44 yards for a touchdown, which gave them a 17-10 lead over the Browns with 3:55 to play in the first half.
Here is the play Kizer was injured on.
The Lions are now 5-4 entering next Sunday afternoon's trip to meet their longtime rival, the Chicago Bears, at Soldier Field on the shores of Lake Michigan.
The Brown had runs of 21, four, six, 19, 14 and six on this touchdown drive to knot the score at 17 in the third quarter.
An undermanned roster led 24-17 in the third quarter, but the Browns' defense could not sustain some early success and was eventually overwhelmed.
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Kizer left the game with a rib injury after taking a hit from Quandre Diggs.
After a sluggish start that saw them go three-and-out on their first drive before Stafford threw an interception on the second, the Lions' offense produced 31 points against one of the stingiest defensive units in the league.
What it means: If the Browns played this way all season, there would be unhappiness about the record but credit for an undermanned team competing to win.
The Browns were driving as time elapsed when Detroit's Darius Slay intercepted Kizer in the end zone to set the final score. I saw a better version of him today.
The Lions woke up in the second quarter, with a balanced attack setting up a field goal and a touchdown run. That gave them the 24-17 lead, but the Lions tied the game, setting up another bad result for the Browns.
It was one of those play calls that the Browns have become known for, one that fans wish they could unsee after it unfolds. Crowell and Johnson each contributed, as the Browns showed the design they had to win games this season can work when they actually follow the plan.