If it did not, the Commission said, it faced penalty payments of up to 5 per cent of the average daily worldwide turnover of Alphabet, which is Google's parent company.
The company has submitted plans on how it plans to stop favouring its shopping service and these are now being reviewed by Brussels.
A Google spokeswoman declined to comment.
The appeal lodged by Google will not help it to suspend the fine, however, it can put the money in a blocked account until the final decision.
PSG 'will rest Neymar against Metz' to save him for Celtic tie
The long-serving Arsenal manager even went as far to compare Mbappe to one of the game's greatest ever players. Neymar also scored in the demolition of Metz .
The consideration of this appeal should take at least a year and a half, and given the complexity of the case, rather two years, has there shown to the Court of justice of the EU. Previously it had stated that it "respectfully" disagreed with the Commission's decision. "And most importantly, it denied European consumers a genuine choice of services and the full benefits of innovation".
Google is fighting its record $2.7 billion antitrust fine from the European Commission.
Regulators are also expected to levy fines in separate investigations into Google's Android mobile-phone software - possibly as soon as next month - and the AdSense advertising service.
The Google case differs from Intel's, but the judgment has been welcomed by companies under European Union scrutiny because it raises the bar for the regulator to prove wrongdoing.
The EU is now also investigating whether Google tried to squeeze out its rivals in online search advertising and through its Android mobile operating system.