Earlier, Babar Azam continued his fine form with a 38-ball 45 while Ahmed Shehzad and Shoaib Malik made 43 and 39 runs respectively as Pakistan managed 174-6 in their allotted 20 overs.
After World XI won the toss and opting to field, bowlers failed to click as Pakistan's Ahmed Shazad (89) and Babar Azam (48) thrashed the visitors all around the park.
Pakistan cricket Board arranged separate rides for the two star players in "rikshaws" as soon as the Pakistan innings was completed during the match.
That left the series intriguingly placed with the final match on Friday, also in Lahore.
Du Plessis (13) was run out by a sharp piece of work by Shadab Khan whose direct hit found the skipper short of his ground despite a despairing dive.
The charged crowd repeated chanted slogans in recognition of their meritorious services for the Pakistan cricket.
With the World XI side having five South African stars - skipper Du Plessis, Hashim Amla, Imran Tahir, Morne Morkel and David Miller - in its fold, there is no questioning that while this is an worldwide effort, to help Pakistan out of its isolation, its roots are firmly entrenched in Southern Africa.
The first T20I between Pakistan and the World XI took place under massive security presence
David Miller and Thisara Perera scored 32 each while Hasan Ali took 2-28.
Faf du Plessis-led World XI will look for a repeat performance and seal the series when they play Pakistan in the final T20 match at Gaddafi stadium. His 55-ball knock included eight fours and three sixes.
Ahmed missed his second T20 global century when he fell for 89. They lost 6 wickets to Ben Cutting (1), Samuel Badree (2), Thisara Perera (2), and Imran Tahir (1).
"On a more personal note, I have a strong bond with Pakistan, having toured here with the Zimbabwe cricket team in 1993, 1996 and 1998, " Flower said.
"We owe all players of the visiting team for helping Pakistan restore global cricket in the country", Lahore resident Uzma Hussain told Reuters.
Sethi said the tour by the West Indies is an important milestone as it would be a proper bilateral series in Pakistan and it would open the windows for the PCB to negotiate with other cricket playing nations.
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