Northumbria Police said the blast was caused by a gas explosion.
The North East Ambulance Service confirmed: "We have been made aware of an incident at a private address on Rosslyn Avenue in Ryhope, Sunderland".
In a post on a local community group, she wrote: "There must b a God sum where, how the hell can anyone survive that explosion".
She was treated for burns and rushed to Newcastle Royal Victoria Infirmary in a serious but stable condition.
In a statement, Northern Gas said: "Emergency engineers from Northern Gas Networks (NGN) attended the scene of an incident on Rosslyn Avenue in Ryhope, Sunderland on the morning of Friday 11 August".
The witness also described the chaotic scene with people "running all over, not knowing what to do".
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A woman on a neighbouring street said half of the semi-detached house had been flattened by the explosion.
Neighbour Tracey Pounder said: 'I heard an almighty bang.
NHS Head Chef Jacqueline, who lives around the corner from Susan, said: "I was walking up the stairs and I said to my daughter have you dropped my iPad?"
"Half of the semi has gone and next door is wrecked". I came down to see what was happening and it is a complete shock'.
The sound of the explosion at 8.48am could be heard more than a mile away in Grangetown, Hill View and Hendon. He added: "I saw the window move and the house shook".