The show saw performances from big pop acts from both sides of the Atlantic, including local heroes Take That and Liam Gallagher, along with Pharrell Williams, Katy Perry, Justin Bieber, Little Mix, Coldplay, the Black Eyed Peas, and Grande.
Every artist had an emotional message for the audience, with common threads of togetherness and love prevailing in each one.
"We're broken-hearted for children who lost their parents and parents who lost their children from this senseless, senseless horror", he said. We love you and we are with you. "We'll see you again when the stars fall from the sky".
Few fans has earlier questioned whether Sunday's show would go on after three armed men drove a van into a crowd on the London Bridge on Saturday night and another incident was reported at the Borough Market in London.
Thornton and Tia Larson, 16, and were at the Manchester Arena when the suicide bomber struck.
After that performance, Grande introduced her boyfriend, rapper Mac Miller, to the stage to sing "The Way", which they collaborated on in 2013.
"We honour you and we love you!"
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"Finally, our thoughts remain with all those affected by the heartbreaking events of Monday May 22". "Hatred will never win, fear will never divide us, because on this day we all stood with Manchester". The Oasis song was one crowds in Manchester sang during a vigil for the victims.
"Today's One Love Manchester benefit concert will not only continue, but will do so with greater objective", Braun said in a statement.
The front section of the Old Trafford Cricket Ground crowd was reserved for those who had been at Grande's show on May 22.
Those who had attended Grande's May 22 concert were offered free tickets to the Sunday show, while the 35,000 tickets put up for sale on Thursday at £40 each (RM220) sold out in minutes.
Before the show, Grande's manager Scooter Braun released a statement vowing that the show would go on. You looked fear in the face and said, 'No.
Ariana then opened up about meeting one of the victims' mother over the weekend and how that experience changed the entire set list for the concert.
He shared just how grateful he was to part of a wonderful night by tweeting, "First of all thank you manchester".