The 21-year-old Hamou, a French qualifier who lost to Pablo Cuevas in the first round on Monday, also held the Eurosport TV journalist around her neck as she tried to move away during a live interview at Roland Garros.
The fourth-seeded Muguruza won 15 points in a row from being up 3-2 in the first set and broke her Italian opponent five times.
"I just played very bad games on my serve", he admitted after his 6-3 6-4 6-2 win.
Frenchman Gilles Simon was another seed to go out after a 1-6 6-2 6-4 6-1 defeat to Nikoloz Basilashvili of Georgia, while 32-seed Mischa Zverev of Germany crahed out at the hands of Italy's Stefano Napolitano 4-6 7-5 6-2 6-2. "But it's hard to say whether there is significant difference on the court, because it's only a few days that we are together", added Djokovic. I know how to do this really well. He has been through that and he has a lot to share with me outside and inside of the tennis lines. "That's great for me", Nadal said of his preparations.
"During the second set, I was careful to hit at his forehand, but then my forehand crosscourt is my best shot, and I realised that I could use this type of shot, as well".
Djokovic, 30, found little resistance from Granollers, grabbing two breaks early on in the first set and powering to a 6-3 6-4 6-2 victory. "Now I have to play well here".
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Kerr had his initial procedures in 2015 after guiding the organization's first championship in 40 years as a rookie coach. Last couple weeks have been good in terms of running practice, film sessions, coaches meetings, that kind of stuff.
Kiki Bertens of the Netherlands recovered from a set down to beat Australian Ajla Tomljanovic and reach the second round of the French Open.
In the second round Nadal will play Dutchman Robin Haase.
Muguruza, who stunned Serena Williams in last year's final, triumphed 6-2, 6-4 to set-up a second round clash with Anett Kontaveit of Estonia. The 20-year-old Zverev defeated Djokovic in Rome a week ago to become the first player born in the 1990s to land a Masters title.
There was a huge scare for former finalist David Ferrer as he needed a 13-11 win in the fifth set to see off Donald Young, while French hope Richard Gasquet battled past Arthur De Greef 6-2 3-6 6-1 6-3.
Kristina Mladenovic of France celebrates winning her first round match against Jennifer Brady on day two of the French Open at Roland Garros in Paris. "Then he has to leave, because he has already scheduled some things that he can not reschedule", Djokovic said.
First up on Court Philippe Chatrier is seventh-seeded Johanna Konta against Su-Wei Hsieh.