It was a game that Barcelona deserved to win as they dominated the match 69-31 per cent.
Messi is also the first player in Europe's top 5 leagues to hit 50 goals this season.
Carlos Carmona got the only goal midway through the second half to move Sporting to within three points of Leganes with two games remaining.
Neymar took advantage of a blocked shot from Messi to prod home the opener from close range after 21 minutes.
"We know how hard it is to play against Barcelona at the Camp Nou". While the Uruguay global Suarez now earns a reported £230,000 a week at Barcelona, while Neymar saw his pay packet increase to £425,000-a-week with his release clause rising to €200m.
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James Rodriguez put Zinedine Zidane's side in charge in the third minute by bundling in Lucas Vazquez's arrowed cross and then headed in a cross from forgotten man Fabio Coentrao to double their lead in the 11th, scoring for the fifth time in four games.
But Enrique is focused exclusively on securing three points against a Villarreal side who are hoping to keep their European ambitions alive following three successive league victories, including a 1-0 win at Champions League semi-finalists Atletico Madrid. The Argentine, who has four goals in his last three matches, is therefore happy to wait before tying his future down at the Catalan club.
He subsequently scored from the penalty spot to make it 4-1 in the second half for Barca, taking his tally for the season to 51 goals.
Messi has done the most damage with 50 goals in all competitions, Suarez scoring 34 and Neymar chipping in with 16. They are the only team in the league this season to win both league games against Atletico Madrid and held fourth-placed Sevilla to two draws.
Here is how he fared at the Nou Camp on Saturday evening as he helped Barca pile more pressure on Real Madrid at the top of the table. The team has conceded fewer goals than any team except for Atletico Madrid. They're also in great form in the league, winning five of their last six games - holding five of the six teams to a goal or less during that stretch.